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John Wayne Casserole

John Wayne Casserole is a delicious ground beef and biscuit casserole. This famous ground beef casserole is loaded with Mexi-corn, Rotel, taco seasoning, biscuits, and more. A must make comfort food for any night of the week. Give this casserole recipe a try today.
Course Dinner
Cuisine American
Keyword bisquick recipe, casserole recipe, casserole recipes, casserole with ground beef, crockpot casserole, easy casserole, easy dinner, easy meal, ground beef and biscuits, ground beef casserole, ground beef casserole recipe, ground beef dinner, John Wayne casserole, John Wayne casserole recipe, layered hamburger casserole, mexican casserole
Prep Time 10 minutes
Cook Time 40 minutes
Total Time 50 minutes
Servings 9 x13
Calories 467kcal
Author Kelsey

Ingredients

  • 1 pound ground beef
  • 1 packet taco seasoning or 2 tablespoons homemade
  • 1/4 cup water
  • 1/2 yellow onion diced
  • 1 can Rotel drained (20 ounces)
  • 1 can Mexi Corn drained (7 ounces)

Biscuit Layer

  • 3 cups Bisquick
  • 1 cup water

Cream Cheese Topping

  • 1/2 cup mayonnaise
  • 8 ounces cream cheese softened
  • 1/2 teaspoon garlic salt
  • 1/2 teaspoon onion powder

Cheese Topping

  • 1 1/2 cup mozzarella
  • 1 cup sharp cheese

Instructions

  • Preheat the oven to 350 degrees. Then grease your 9x13 pan and set it aside.
  • Start by cooking your ground beef in a skillet on the stove. Toss in the diced onions to cook with the meat.
  • Once done drain off the grease, and then add the taco seasoning and water. Stir to coat all the meat in the taco seasoning.
  • Next, add in the drained corn and Rotel and mix well. Leave on simmer stirring occasionally.
  • In a bowl you will add your Bisquick and the cup of water. Mix well and this will be a thicker texture. Pour into the 9x13 pan spreading it out evenly.
  • Top with the ground beef mixture, spreading evenly.
  • In a stand mixer or with a hand mixer add the softened cream cheese, mayonnaise, garlic salt, and onion powder. Mix till creamy and pour on top of the meat.
  • Top with both blends of cheese.
  • Bake for 35-40 minutes or until the cheese is melted and the top has a slight golden brown color.
  • Once the John Wayne casserole is done, you can allow to cool for about 5 minutes, and then slice and serve!

Notes

Rotel - If you don't have Rotel, use 1 can diced tomatoes, and 1 small can green chilies, drained. That is what Rotel is.
Corn - If you don't want to use Mexi-corn you can use a classic corn or leave it out.
Mayo Swap - If you do not want to use mayonnaise with the cream cheese you can swap with sour cream or a plain Greek yogurt.
Cheese - We love cheese but if you want less cheese you can do 1/2 cup mozzarella and 1/2 cup sharp to make it less cheesy.

Nutrition

Serving: 1g | Calories: 467kcal | Carbohydrates: 26g | Protein: 20g | Fat: 31g | Saturated Fat: 12g | Polyunsaturated Fat: 16g | Cholesterol: 78mg | Sodium: 1064mg | Fiber: 1g | Sugar: 5g